Investigation of frailty markers including a novel biomarker panel in emergency laparotomy: protocol of a prospective cohort study.

ABSTRACT:

Background

Emergency laparotomy (EmLAP) is one of the commonest emergency operations performed in the United Kingdom (approximately 30, 000 laparotomies annually). These potentially high-risk procedures can be life changing with frail patients and/ or older adults (≥ 65 years) having the poorest outcomes, including mortality. There is no gold standard of frailty assessment and no clinical chemical biomarkers existing in practice. Early detection of subclinical changes or deficits at the molecular level are essential in improving our understanding of the biology of frailty and ultimately improving patient outcomes. This study aims primarily to compare preoperative frailty markers, including a blood-based biomarker panel, in their ability to predict 30 and 90-day mortality post-EmLAP

SUBMITTER: Ng HJ 

PROVIDER: S-EPMC10321009 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature