Breaking down the tumor immune infiltration within pediatric sarcomas.
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ABSTRACT:
SUBMITTER: Weil R
PROVIDER: S-EPMC10324675 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Breaking down the tumor immune infiltration within pediatric sarcomas.
Frontiers in endocrinology 20230622
Immunotherapies are a promising therapeutic option, yet for a variety of reasons, these treatments have achieved limited success against sarcomas. The immunosuppressive tumor microenvironment (TME) of sarcomas as well as lack of predictive biomarkers, decreased T-cell clonal frequency, and high expression of immunosuppressive infiltrating cells has thus far prevented major success using immunotherapies. By breaking down the TME into its individual components and understanding how the various cel ...[more]
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