Dataset Information

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Objective

The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence.

Methods

A two-sample Mendelian randomization (MR) study was conducted using inverse variance weighting (IVW), weighted median, and MR-Egger regression techniques Publicly accessible summary statistics dataset of intestinal microbiomes of European descent from genome-wide association studies (GWASs) (a total with 3,326 individuals) was used as an exposure As an outcome, summary data from the GWAS include 3,498 patients with OA of the knee and hip from the arcOGEN sample and 11,009 controls of European descent.

Results

We identified 29 single-nucleotide polymorphisms from GWAS of intestinal microbiomes as instrumental variables The IVW approach found no evidence to suggest a causal relationship between the intestinal microbiota and OA (beta=-0001, standard error [SE]=0004, p=0748) The regression test of MR-Egger showed that the directional pleiotropy was unlikely to be a bias (intercept=0002, SE=0007, p=0697) and the MR-Egger study showed no causal relation between the intestinal microbiota and the OA (beta=-0002, SE=0005, p=0630) The weighted median analysis also did not have indications of a causal relationship between the intestinal microbiota and OA (beta=-0002, SE=0005, p=0630) The MR results calculated using IVW, the median weighted and the MR-Egger regression approaches were consistent.

Conclusion

The findings of the MR analysis did not support a causal relationship between intestinal microbiome and OA risk.

SUBMITTER: Lee YH

PROVIDER: S-EPMC10324885 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

Lee Young Ho YH Song Gwan Gyu GG

Journal of rheumatic diseases 20210401 2

<h4>Objective</h4>The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence.<h4>Methods</h4>A two-sample Mendelian randomization (MR) study was conducted using inverse variance weighting (IVW), weighted median, and MR-Egger regression techniques Publicly accessible summary statistics dataset of intestinal microbiomes of European descent from genome-wide association studies (GWASs) (a total with 3,326 individuals) was used as an ex ...[more]

PMID: 37476017

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Project description:BackgroundThe causal association between gut microbiome and HIV infection remains to be elucidated. We conducted a two-sample mendelian randomization analysis to estimate the causality between gut microbiome and HIV infection.MethodsPublicly released genome-wide association studies summary data were collected to perform the mendelian analysis. The GWAS summary data of gut microbiome was retrieved from the MiBioGen consortium, which contains 18 340 samples from 24 cohorts. GWAS summary data of HIV infection was collected from the R5 release of FinnGen consortium, including 357 HIV infected cases and 218 435 controls. The SNPs were selected as instrumental variables according to our selection rules. And SNPs with a F-statistics less than ten were regarded as weak instrumental variables and excluded. Mendelian randomization analysis was conducted by five methods, including inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode. The Cochran's Q test and MR-Egger intercept test were performed to identify heterogeneity and pleiotropy. Leave-one-out analysis were used to test the sensitivity of the results.ResultsFifteen gut microbiota taxa showed causal effects on HIV infection according to the MR methods. Four taxa were observed to increase the risk of HIV infection, including Ruminococcaceae (OR: 2.468[1.043, 5.842], P: 0.039), Ruminococcaceae UCG005 (OR: 2.051[1.048, 4.011], P: 0.036), Subdoligranulum (OR: 3.957[1.762, 8.887], P < 0.001) and Victivallis (OR: 1.605[1.012, 2.547], P=0.044). Erysipelotrichaceae was protective factor of HIV infection (OR: 0.278[0.106, 0.731], P < 0.001) and Methanobrevibacter was also found to be associated with reduced risk of HIV infection (OR: 0.509[0.265, 0.980], P=0.043). Horizontal pleiotropy was found for Fusicatenibacter (P<0.05) according to the MR-Egger regression intercept analysis. No heterogeneity was detected.ConclusionOur results demonstrate significant causal effects of gut microbiome on HIV infection. These findings facilitate future studies to develop better strategies for HIV prophylaxis through gut microbiome regulation. Further explorations are also warranted to dissect the mechanism of how gut microbiome affects HIV susceptibility.

Dataset Information

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

Objective

Methods

Results

Conclusion

Publications

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

Similar Datasets

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