Ontology highlight
ABSTRACT:
SUBMITTER: Peng Y
PROVIDER: S-EPMC10327179 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Peng Yunhui Y Song Wei W Teif Vladimir B VB Ovcharenko Ivan I Landsman David D Panchenko Anna R AR
bioRxiv : the preprint server for biology 20231123
Wrapping of DNA into nucleosomes restricts accessibility to the DNA and may affect the recognition of binding motifs by transcription factors. A certain class of transcription factors, the pioneer transcription factors, can specifically recognize their DNA binding sites on nucleosomes, may initiate local chromatin opening and facilitate the binding of co-factors in a cell-type-specific manner. For the majority of human pioneer transcription factors, the locations of their binding sites, mechanis ...[more]