Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Bernalt Diego J
PROVIDER: S-EPMC10327228 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20230523
Hybrid immunity to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. mRNA vaccine, BNT162b2, was dosed to induce binding antibody titers against ancestral spike, but inefficient serum virus neutralization of ancestral SARS-CoV-2 or variants of concern (VoCs). Vaccination reduced morbidity and controlled lung virus titers for ancestral virus and Alpha but ...[more]