Dataset Information

Strong Genetic Overlaps Between Dimensional and Categorical Models of Bipolar Disorders in a Family Sample.

ABSTRACT:

Objective

Bipolar disorder (BD) often presents with a broad range of symptoms, but there is little agreement as to the heritability and genetic relationships between dimensional and categorical models of this often-disabling disorder.

Methods

Participants in the Amish-Mennonite Bipolar Genetics (AMBiGen) study, which enrolls families with BD and related disorders from Amish and Mennonite communities in North and South America, were assigned a categorical mood disorder diagnosis by structured psychiatric interview and asked to complete the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of cardinal manic symptoms and associated impairment. Principal Component Analysis (PCA) was performed to analyze the dimensions of the MDQ in 726 participants, 212 of whom carried a categorical diagnosis of major mood disorder. SOLAR-ECLIPSE (v9.0.0) was used to estimate heritability and genetic overlaps between MDQ-derived measures and categorical diagnoses among 432 genotyped participants.

Results

As expected, MDQ scores were significantly higher among individuals diagnosed with BD and related disorders. PCA suggested a three-component model for the MDQ, consistent with the literature. Heritability of the MDQ symptom score was estimated at 30% (p<0.001), which was evenly distributed across its three principal components. Strong and significant genetic correlations were found between categorical diagnoses and most MDQ measures, especially impairment.

Conclusion

The results support the MDQ as a dimensional measure of BD. Furthermore, significant heritability and high genetic correlations between MDQ scores and categorical diagnoses suggest a genetic continuity between dimensional and categorical measures of major mood disorders.

SUBMITTER: Arbona-Lampaya A

PROVIDER: S-EPMC10327232 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Strong Genetic Overlaps Between Dimensional and Categorical Models of Bipolar Disorders in a Family Sample.

Arbona-Lampaya Alejandro A Sung Heejong H D'Amico Alexander A Knowles Emma E M EEM Besançon Emily K EK Freifeld Ally A Lacbawan Ley L Lopes Fabiana F Kassem Layla L Nardi Antonio E AE McMahon Francis J FJ

medRxiv : the preprint server for health sciences 20240326

<h4>Background</h4>Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainly, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample.<h4>Methods</h4>Participants in the Amish-Mennonite Bipolar Genetics (AMBiGen) study were assigned categorical mood disorder diagnoses by structured psychiatric interview and completed the Moo ...[more]

PMID: 37425936

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Dataset Information

Strong Genetic Overlaps Between Dimensional and Categorical Models of Bipolar Disorders in a Family Sample.

Objective

Methods

Results

Conclusion

Publications

Strong Genetic Overlaps Between Dimensional and Categorical Models of Bipolar Disorders in a Family Sample.

Similar Datasets

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