Discovery of RNA secondary structural motifs using sequence-ordered thermodynamic stability and comparative sequence analysis.
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ABSTRACT:
SUBMITTER: Peterson JM
PROVIDER: S-EPMC10336498 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Discovery of RNA secondary structural motifs using sequence-ordered thermodynamic stability and comparative sequence analysis.
Peterson Jake M JM O'Leary Collin A CA Coppenbarger Evelyn C EC Tompkins Van S VS Moss Walter N WN
MethodsX 20230629
Major advances in RNA secondary structural motif prediction have been achieved in the last few years; however, few methods harness the predictive power of multiple approaches to deliver in-depth characterizations of local RNA motifs and their potential functionality. Additionally, most available methods do not predict RNA pseudoknots. This work combines complementary bioinformatic systems into one robust discovery pipeline where: •RNA sequences are folded to search for thermodynamically favorabl ...[more]
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