Dataset Information
Association of CSF and PET markers of neurodegeneration with electroclinical progression in Lafora disease.
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ABSTRACT: Purpose
To evaluate the electro-clinical features in association with laboratory and instrumental correlates of neurodegeneration to detect the progression of Lafora disease (LD).Methods
We investigated the electro-clinical longitudinal data and CSF Aβ42, p-tau181 and t-tauAg, amyloid, and 18F-FDG PET of five unrelated LD families.Results
Three progressive electro-clinical stages were identified. The early phase was characterized by rare, generalized tonic-clonic and focal visual seizures, followed by the occurrence of myoclonus after a period ranging from 2 to 12 months. The intermediate stage, usually occurring 2 years after the onset of epilepsy, is characterized by a worsening of epilepsy and myoclonus associated with progressive dementia and cerebellar signs. Finally, the late stage, evolving after a mean period of 7 ± 1.41 years from the onset of the disease, was characterized by gait ataxia resulting in bedriddenness, severe dementia, daily/pluri-daily myoclonus, drug-resistant epilepsy, clusters of seizures or status epilepticus, and medical complications. Amyloid (CSF Aβ42, amyloid PET) and neurodegenerative (CSF p-tau181 and t-tauAg, FDG-PET) biomarkers indicate a pattern of cognitive impairment of the non-Alzheimer's disease type. A total of 80% of the LD patients showed more severe hypometabolism in the second FDG-PET scan compared to the first scan performed in a lower phase; the lateral temporal lobe and the thalamus hypometabolism were associated with the presence of intermediate or late phase.Conclusions
Three electroclinical and 18F-FDG PET evolutive stages are useful biomarkers for the progression of LD and could help to evaluate the efficacy of new disease-modifying treatments. The combination of traditional CSF biomarkers improves the diagnostic accuracy of cognitive decline in LD patients, indicating a cognitive impairment of the non-Alzheimer's disease type.
SUBMITTER: d'Orsi G
PROVIDER: S-EPMC10337130 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Association of CSF and PET markers of neurodegeneration with electroclinical progression in Lafora disease.
Frontiers in neurology 20230628
<h4>Purpose</h4>To evaluate the electro-clinical features in association with laboratory and instrumental correlates of neurodegeneration to detect the progression of Lafora disease (LD).<h4>Methods</h4>We investigated the electro-clinical longitudinal data and CSF Aβ42, p-tau<sub>181</sub> and t-tauAg, amyloid, and <sup>18</sup>F-FDG PET of five unrelated LD families.<h4>Results</h4>Three progressive electro-clinical stages were identified. The early phase was characterized by rare, generalized ...[more]