Dataset Information

Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer.

ABSTRACT:

Purpose

This study was designed to determine the feasibility of preoperative chemoradiotherapy (PCRT) in patients with clinical T2N0 distal rectal cancer.

Methods

Patients who underwent surgery for clinical T2N0 distal rectal cancer between January 2008 and December 2016 were included. Patients were divided into PCRT and non-PCRT groups. Non-PCRT patients underwent radical resection or local excision (LE) according to the surgeon's decision, and PCRT patients underwent surgery according to the response to PCRT. Patients received 50.0 to 50.4 gray of preoperative radiotherapy with concurrent chemotherapy.

Results

Of 127 patients enrolled, 46 underwent PCRT and 81 did not. The mean distance of lesions from the anal verge was lower in the PCRT group (P=0.004). The most frequent operation was transanal excision and ultralow anterior resection in the PCRT and non-PCRT groups, respectively. Of the 46 patients who underwent PCRT, 21 (45.7%) achieved pathologic complete response, including 15 of the 24 (62.5%) who underwent LE. Rectal sparing rate was significantly higher in the PCRT group (11.1% vs. 52.2%, P<0.001). There were no significant differences in 3- and 5-year overall survival and recurrence-free survival regardless of PCRT or surgical procedures.

Conclusion

PCRT in clinical T2N0 distal rectal cancer patients increased the rectal sparing rate via LE and showed acceptable oncologic outcomes. PCRT may be a feasible therapeutic option to avoid abdominoperineal resection in clinical T2N0 distal rectal cancer.

SUBMITTER: Park MY

PROVIDER: S-EPMC10338167 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer.

Park Min Young MY Yu Chang Sik CS Kim Tae Won TW Kim Jong Hoon JH Park Jin-Hong JH Lee Jong Lyul JL Yoon Yong Sik YS Park In Ja IJ Lim Seok-Byung SB Kim Jin Cheon JC

Annals of coloproctology 20220404 3

<h4>Purpose</h4>This study was designed to determine the feasibility of preoperative chemoradiotherapy (PCRT) in patients with clinical T2N0 distal rectal cancer.<h4>Methods</h4>Patients who underwent surgery for clinical T2N0 distal rectal cancer between January 2008 and December 2016 were included. Patients were divided into PCRT and non-PCRT groups. Non-PCRT patients underwent radical resection or local excision (LE) according to the surgeon's decision, and PCRT patients underwent surgery acc ...[more]

PMID: 35368177

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Dataset Information

Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer.

Purpose

Methods

Results

Conclusion

Publications

Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer.

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