Dataset Information

Prediction of miRNA-Disease Associations by Cascade Forest Model Based on Stacked Autoencoder.

ABSTRACT: Numerous pieces of evidence have indicated that microRNA (miRNA) plays a crucial role in a series of significant biological processes and is closely related to complex disease. However, the traditional biological experimental methods used to verify disease-related miRNAs are inefficient and expensive. Thus, it is necessary to design some excellent approaches to improve efficiency. In this work, a novel method (CFSAEMDA) is proposed for the prediction of unknown miRNA-disease associations (MDAs). Specifically, we first capture the interactive features of miRNA and disease by integrating multi-source information. Then, the stacked autoencoder is applied for obtaining the underlying feature representation. Finally, the modified cascade forest model is employed to complete the final prediction. The experimental results present that the AUC value obtained by our method is 97.67%. The performance of CFSAEMDA is superior to several of the latest methods. In addition, case studies conducted on lung neoplasms, breast neoplasms and hepatocellular carcinoma further show that the CFSAEMDA method may be regarded as a utility approach to infer unknown disease-miRNA relationships.

SUBMITTER: Hu X

PROVIDER: S-EPMC10343850 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Prediction of miRNA-Disease Associations by Cascade Forest Model Based on Stacked Autoencoder.

Hu Xiang X Yin Zhixiang Z Zeng Zhiliang Z Peng Yu Y

Molecules (Basel, Switzerland) 20230627 13

Numerous pieces of evidence have indicated that microRNA (miRNA) plays a crucial role in a series of significant biological processes and is closely related to complex disease. However, the traditional biological experimental methods used to verify disease-related miRNAs are inefficient and expensive. Thus, it is necessary to design some excellent approaches to improve efficiency. In this work, a novel method (CFSAEMDA) is proposed for the prediction of unknown miRNA-disease associations (MDAs). ...[more]

PMID: 37446675

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Project description:BackgroundA large body of evidence shows that miRNA regulates the expression of its target genes at post-transcriptional level and the dysregulation of miRNA is related to many complex human diseases. Accurately discovering disease-related miRNAs is conductive to the exploring of the pathogenesis and treatment of diseases. However, because of the limitation of time-consuming and expensive experimental methods, predicting miRNA-disease associations by computational models has become a more economical and effective mean.ResultsInspired by the work of predecessors, we proposed an improved computational model based on random forest (RF) for identifying miRNA-disease associations (IRFMDA). First, the integrated similarity of diseases and the integrated similarity of miRNAs were calculated by combining the semantic similarity and Gaussian interaction profile kernel (GIPK) similarity of diseases, the functional similarity and GIPK similarity of miRNAs, respectively. Then, the integrated similarity of diseases and the integrated similarity of miRNAs were combined to represent each miRNA-disease relationship pair. Next, the miRNA-disease relationship pairs contained in the HMDD (v2.0) database were considered positive samples, and the randomly constructed miRNA-disease relationship pairs not included in HMDD (v2.0) were considered negative samples. Next, the feature selection based on the variable importance score of RF was performed to choose more useful features to represent samples to optimize the model's ability of inferring miRNA-disease associations. Finally, a RF regression model was trained on reduced sample space to score the unknown miRNA-disease associations. The AUCs of IRFMDA under local leave-one-out cross-validation (LOOCV), global LOOCV and 5-fold cross-validation achieved 0.8728, 0.9398 and 0.9363, which were better than several excellent models for predicting miRNA-disease associations. Moreover, case studies on oesophageal cancer, lymphoma and lung cancer showed that 94 (oesophageal cancer), 98 (lymphoma) and 100 (lung cancer) of the top 100 disease-associated miRNAs predicted by IRFMDA were supported by the experimental data in the dbDEMC (v2.0) database.ConclusionsCross-validation and case studies demonstrated that IRFMDA is an excellent miRNA-disease association prediction model, and can provide guidance and help for experimental studies on the regulatory mechanism of miRNAs in complex human diseases in the future.

Dataset Information

Prediction of miRNA-Disease Associations by Cascade Forest Model Based on Stacked Autoencoder.

Publications

Prediction of miRNA-Disease Associations by Cascade Forest Model Based on Stacked Autoencoder.

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