Dataset Information

Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France.

ABSTRACT:

Background

The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed.

Methods

In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay.

Results

The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 year^-1 for children, and 0.13-0.27 year^-1 for adults. Seroreversion was estimated as 0.31-1.37 year^-1 in children and 0.19-0.72 year^-1 in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV.

Conclusions

The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children.

SUBMITTER: De Thoisy A

PROVIDER: S-EPMC10368309 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France.

De Thoisy Alix A Woudenberg Tom T Pelleau Stéphane S Donnadieu Françoise F Garcia Laura L Pinaud Laurie L Tondeur Laura L Meola Annalisa A Arowas Laurence L Clement Nathalie N Backovic Marija M Ungeheuer Marie-Noëlle MN Fontanet Arnaud A White Michael M

Open forum infectious diseases 20230703 7

<h4>Background</h4>The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed.<h4>Methods</h4>In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay.<h4>Results</h4>The rat ...[more]

PMID: 37496603

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Dataset Information

Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France.

Background

Methods

Results

Conclusions

Publications

Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France.

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