Dataset Information

Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.

ABSTRACT:

Purpose

We developed a method of standardizing the heart-to-mediastinal ratio in ¹²³I-labeled meta-iodobenzylguanidine (MIBG) images using a conversion coefficient derived from a dedicated phantom. This study aimed to create a machine-learning (ML) model to estimate conversion coefficients without using a phantom.

Methods

210 Monte Carlo (MC) simulations of ¹²³I-MIBG images to obtain conversion coefficients using collimators that differed in terms of hole diameter, septal thickness, and length. Simulated conversion coefficients and collimator parameters were prepared as training datasets, then a gradient-boosting ML was trained to estimate conversion coefficients from collimator parameters. Conversion coefficients derived by ML were compared with those that were MC simulated and experimentally derived from 613 phantom images.

Results

Conversion coefficients were superior when estimated by ML compared with the classical multiple linear regression model (root mean square deviations: 0.021 and 0.059, respectively). The experimental, MC simulated, and ML-estimated conversion coefficients agreed, being, respectively, 0.54, 0.55, and 0.55 for the low-; 0.74, 0.70, and 0.72 for the low-middle; and 0.88, 0.88, and 0.88 for the medium-energy collimators.

Conclusions

The ML model estimated conversion coefficients without the need for phantom experiments. This means that conversion coefficients were comparable when estimated based on collimator parameters and on experiments.

SUBMITTER: Okuda K

PROVIDER: S-EPMC10372132 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.

Okuda Koichi K Nakajima Kenichi K Kitamura Chiemi C Ljungberg Michael M Hosoya Tetsuo T Kirihara Yumiko Y Hashimoto Mitsumasa M

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20230205 4

<h4>Purpose</h4>We developed a method of standardizing the heart-to-mediastinal ratio in <sup>123</sup>I-labeled meta-iodobenzylguanidine (MIBG) images using a conversion coefficient derived from a dedicated phantom. This study aimed to create a machine-learning (ML) model to estimate conversion coefficients without using a phantom.<h4>Methods</h4>210 Monte Carlo (MC) simulations of <sup>123</sup>I-MIBG images to obtain conversion coefficients using collimators that differed in terms of hole dia ...[more]

PMID: 36740650

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Dataset Information

Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.

Purpose

Methods

Results

Conclusions

Publications

Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.

Similar Datasets

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