Ontology highlight
ABSTRACT:
SUBMITTER: Rodak O
PROVIDER: S-EPMC10379584 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Rodak Olga O Mrozowska Monika M Rusak Agnieszka A Gomułkiewicz Agnieszka A Piotrowska Aleksandra A Olbromski Mateusz M Podhorska-Okołów Marzenna M Ugorski Maciej M Dzięgiel Piotr P
International journal of molecular sciences 20230711 14
The transcription factor SOX18 has been shown to play a crucial role in lung cancer progression and metastasis. In this study, we investigated the effect of Sm4, a SOX18 inhibitor, on cell cycle regulation in non-small cell lung cancer (NSCLC) cell lines LXF-289 and SK-MES-1, as well as normal human lung fibroblast cell line IMR-90. Our results demonstrated that Sm4 treatment induced cytotoxic effects on all three cell lines, with a greater effect observed in NSCLC adenocarcinoma cells. Sm4 trea ...[more]