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ABSTRACT:
SUBMITTER: Hoskins J
PROVIDER: S-EPMC103796 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
Hoskins J J Matsushima P P Mullen D L DL Tang J J Zhao G G Meier T I TI Nicas T I TI Jaskunas S R SR
Journal of bacteriology 19991001 20
The effects of inactivation of the genes encoding penicillin-binding protein 1a (PBP1a), PBP1b, and PBP2a in Streptococcus pneumoniae were examined. Insertional mutants did not exhibit detectable changes in growth rate or morphology, although a pbp1a pbp1b double-disruption mutant grew more slowly than its parent did. Attempts to generate a pbp1a pbp2a double-disruption mutant failed. The pbp2a mutants, but not the other mutants, were more sensitive to moenomycin, a transglycosylase inhibitor. T ...[more]