Dataset Information

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.

ABSTRACT:

Introduction

The influence of myelination on longitudinal changes in cognitive performance remains unclear.

Methods

For each participant (N = 123), longitudinal cognitive scores were calculated. Myelin content was probed using myelin water fraction (MWF) or longitudinal relaxation rate (R₁ ); both are MRI measures sensitive to myelin, with MWF being specific.

Results

Lower MWF was associated with steeper declines in executive function (p < .02 in all regions) and lower R₁ was associated with steeper declines in verbal fluency (p < .03 in all regions). Additionally, lower R₁ was associated with steeper declines in executive function (p < .02 in all regions) and memory (p < .04 in occipital and cerebral white matter) but did not survive Bonferroni correction.

Discussion

We demonstrate significant relationships between myelin content and the rates of change in cognitive performance among cognitively normal individuals. These findings highlight the importance of myelin in cognitive functioning and suggest MWF and R₁ as imaging biomarkers to predict cognitive changes.

SUBMITTER: Gong Z

PROVIDER: S-EPMC10387505 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.

Gong Zhaoyuan Z Bilgel Murat M Kiely Matthew M Triebswetter Curtis C Ferrucci Luigi L Resnick Susan M SM Spencer Richard G RG Bouhrara Mustapha M

Alzheimer's & dementia : the journal of the Alzheimer's Association 20230131 7

<h4>Introduction</h4>The influence of myelination on longitudinal changes in cognitive performance remains unclear.<h4>Methods</h4>For each participant (N = 123), longitudinal cognitive scores were calculated. Myelin content was probed using myelin water fraction (MWF) or longitudinal relaxation rate (R<sub>1</sub> ); both are MRI measures sensitive to myelin, with MWF being specific.<h4>Results</h4>Lower MWF was associated with steeper declines in executive function (p < .02 in all regions) and ...[more]

PMID: 36720000

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Dataset Information

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.

Introduction

Methods

Results

Discussion

Publications

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.

Similar Datasets

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