The impact of cancer cachexia on gut microbiota composition and short-chain fatty acid metabolism in a murine model.
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ABSTRACT:
SUBMITTER: Jeong SM
PROVIDER: S-EPMC10390285 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
The impact of cancer cachexia on gut microbiota composition and short-chain fatty acid metabolism in a murine model.
Jeong Seung Min SM Jin Eun-Ju EJ Wei Shibo S Bae Ju-Hyeon JH Ji Yosep Y Jo Yunju Y Jeong Jee-Heon JH Im Se Jin SJ Ryu Dongryeol D
BMB reports 20230701 7
This study investigates the relationship between cancer cachexia and the gut microbiota, focusing on the influence of cancer on microbial composition. Lewis lung cancer cell allografts were used to induce cachexia in mice, and body and muscle weight changes were monitored. Fecal samples were collected for targeted metabolomic analysis for short chain fatty acids and microbiome analysis. The cachexia group exhibited lower alpha diversity and distinct beta diversity in gut microbiota, compared to ...[more]
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