The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes.
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ABSTRACT:
SUBMITTER: Kobayashi R
PROVIDER: S-EPMC10392064 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes.
Kobayashi Ryota R Hoshikawa Emi E Saito Taisuke T Suebsamarn Orakarn O Naito Eriko E Suzuki Ayako A Ishihara Seiichiro S Haga Hisashi H Tomihara Kei K Izumi Kenji K
FEBS open bio 20230604 8
We previously reported that the cell and colony motion of oral keratinocytes are correlated with proliferative capacity, and speculated that this may be a specific index for monitoring cell quality. However, how cell motility and proliferation are regulated by signaling pathways remains unelucidated. Here, we found that the regulation of cell motility and proliferative capacity of oral keratinocytes can be attributed to the epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) axis ...[more]
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