Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study.

ABSTRACT:

Objective

Hepatitis E virus (HEV) infections are common, self-limiting causes of acute viral hepatitis. This study aimed to analyze hepatic injury, viremia, and chronicity rates in patients with acute HEV infection receiving immunosuppressive (IS) therapy taking into account ribavirin treatment.

Methods

In this retrospective, single-center, observational study, we analyzed the disease course of 25 non-cirrhotic patients receiving IS therapy who were diagnosed with acute HEV viremia. Forty-four patients with acute HEV viremia without IS therapy were controls.

Results

Demographics, symptoms at presentation, and extrahepatic manifestations were not different between patients with and without IS therapy, but liver injury at presentation was less severe in patients with IS

SUBMITTER: Franz A 

PROVIDER: S-EPMC10392516 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature