E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.
Ontology highlight
ABSTRACT: Aims
Abdominal aortic aneurysm (AAA) is a common cardiovascular disease with a strong correlation to smoking, although underlying mechanisms have been minimally explored. Electronic cigarettes (e-cigs) have gained recent broad popularity and can deliver nicotine at comparable levels to tobacco cigarettes, but effects on AAA development are unknown.Methods and results
We evaluated the impact of daily e-cig vaping with nicotine on AAA using two complementary murine models and found that exposure enhanced aneurysm development in both models and genders. E-cigs induced changes in key mediators of AAA development including cytokine chitinase-3-like protein 1 (CHI3L1/Chil1) and its targeting microRNA-24 (miR-24). We show that nicotine triggers inflammatory signalling and reactive oxygen species while modulating miR-24 and CHI3L1/Chil1 in vitro and that Chil1 is crucial to e-cig-augmented aneurysm formation using a knockout model.Conclusions
In conclusion our work shows increased aneurysm formation along with augmented vascular inflammation in response to e-cig exposure with nicotine. Further, we identify Chil1 as a key mediator in this context. Our data raise concerns regarding the potentially harmful long-term effects of e-cig nicotine vaping.
SUBMITTER: Mulorz J
PROVIDER: S-EPMC10409905 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Publications
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.
Mulorz Joscha J Spin Joshua M JM Mulorz Pireyatharsheny P Wagenhäuser Markus Udo MU Deng Alicia A Mattern Karin K Rhee Yae H YH Toyama Kensuke K Adam Matti M Schelzig Hubert H Maegdefessel Lars L Tsao Philip S PS
Cardiovascular research 20230501 3
<h4>Aims</h4>Abdominal aortic aneurysm (AAA) is a common cardiovascular disease with a strong correlation to smoking, although underlying mechanisms have been minimally explored. Electronic cigarettes (e-cigs) have gained recent broad popularity and can deliver nicotine at comparable levels to tobacco cigarettes, but effects on AAA development are unknown.<h4>Methods and results</h4>We evaluated the impact of daily e-cig vaping with nicotine on AAA using two complementary murine models and found ...[more]
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