Unknown

Dataset Information

0

NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis.


ABSTRACT: Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian Nematostella vectensis as a model to provide new insights into the molecular regulation of non-ectodermal neurogenesis. We show that the transcription factor NvPrdm14d is expressed in a subpopulation of NvSoxB(2)-expressing endodermal progenitor cells and their NvPOU4-expressing progeny. Using a new transgenic reporter line, we show that NvPrdm14d-expressing cells give rise to neurons in the body wall and in close vicinity of the longitudinal retractor muscles. RNA-sequencing of NvPrdm14d::GFP-expressing cells and gene knockdown experiments provide candidate genes for the development and function of these neurons. Together, the identification of a population of endoderm-specific neural progenitor cells and of previously undescribed putative motoneurons in Nematostella provide new insights into the regulation of non-ectodermal neurogenesis.

SUBMITTER: Lemaitre QIB 

PROVIDER: S-EPMC10415408 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis.

Lemaître Quentin I B QIB   Bartsch Natascha N   Kouzel Ian U IU   Busengdal Henriette H   Richards Gemma Sian GS   Steinmetz Patrick R H PRH   Rentzsch Fabian F  

Nature communications 20230810 1


Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian Nematostella vectensis as a model to provide new insights into the molecular regulation of non-ectodermal neurogenesis. We show that the transcription factor NvPrdm14d is expressed in a subpopulation of NvSoxB(2)-expressing endodermal progenitor cells and their NvPOU4-expres  ...[more]

Similar Datasets

| S-EPMC3274362 | biostudies-literature
| S-EPMC4968017 | biostudies-literature
| S-EPMC8786827 | biostudies-literature
| S-EPMC3793345 | biostudies-literature
| S-EPMC4580332 | biostudies-literature
| S-EPMC6698014 | biostudies-literature
| PRJNA598421 | ENA
| PRJNA394979 | ENA
| PRJNA449935 | ENA
| PRJNA371415 | ENA