Dataset Information

Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes.

ABSTRACT:

Study design

International multicenter prospective observational cohort study on patients undergoing radiation +/- surgical intervention for the treatment of symptomatic spinal metastases.

Objectives

To investigate the association between the total Spinal Instability Neoplastic Score (SINS), individual SINS components and PROs.

Methods

Data regarding patient demographics, diagnostics, treatment, and PROs (SF-36, SOSGOQ, EQ-5D) was collected at baseline, 6 weeks, and 12 weeks post-treatment. The SINS was assessed using routine diagnostic imaging. The association between SINS, PRO at baseline and change in PROs was examined with the Spearmans rank test.

Results

A total of 307 patients, including 174 patients who underwent surgery+/- radiotherapy and 133 patients who underwent radiotherapy were eligible for analyses. In the surgery+/- radiotherapy group, 18 (10.3%) patients with SINS score between 0-6, 118 (67.8%) with a SINS between 7-12 and 38 (21.8%) with a SINS between 13-18, as compared to 55 (41.4%) SINS 0-6, 71(53.4%) SINS 7-12 and 7 (5.2%) SINS 13-18 in the radiotherapy alone group. At baseline, the total SINS and the presence of mechanical pain was significantly associated with the SOSGOQ pain domain (r = -0.519, P < 0.001) and the NRS pain score (r = 0.445, P < 0.001) for all patients. The presence of mechanical pain demonstrated to be moderately associated with a positive change in PROs at 12 weeks post-treatment.

Conclusion

Spinal instability, as defined by the SINS, was significantly correlated with PROs at baseline and change in PROs post-treatment. Mechanical pain, as a single SINS component, showed the highest correlations with PROs.

SUBMITTER: Versteeg AL

PROVIDER: S-EPMC10416601 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes.

Versteeg Anne L AL Sahgal Arjun A Laufer Ilya I Rhines Laurence D LD Sciubba Daniel M DM Schuster James M JM Weber Michael H MH Lazary Aron A Boriani Stefano S Bettegowda Chetan C Fehlings Michael G MG Clarke Michelle J MJ Arnold Paul M PM Gokaslan Ziya L ZL Fisher Charles G CG

Global spine journal 20210726 5

<h4>Study design</h4>International multicenter prospective observational cohort study on patients undergoing radiation +/- surgical intervention for the treatment of symptomatic spinal metastases.<h4>Objectives</h4>To investigate the association between the total Spinal Instability Neoplastic Score (SINS), individual SINS components and PROs.<h4>Methods</h4>Data regarding patient demographics, diagnostics, treatment, and PROs (SF-36, SOSGOQ, EQ-5D) was collected at baseline, 6 weeks, and 12 week ...[more]

PMID: 34308697

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Dataset Information

Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes.

Study design

Objectives

Methods

Results

Conclusion

Publications

Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes.

Similar Datasets

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