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Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

ABSTRACT: Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separations using CMOS detectors. The system implements a pulsing strategy to improve the photon flux and uses a data processing pipeline to improve measurement accuracy. We show that SCOS outperforms the current leading optical modality for measuring CBF, i.e. diffuse correlation spectroscopy (DCS), achieving more than 10x SNR improvement at a similar financial cost. Fiber-based SCOS provides an alternative approach to functional neuroimaging for cognitive neuroscience and health science applications.

SUBMITTER: Kim B

PROVIDER: S-EPMC10425329 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

Kim Byungchan B Zilpelwar Sharvari S Sie Edbert J EJ Marsili Francesco F Zimmermann Bernhard B Boas David A DA Cheng Xiaojun X

Communications biology 20230814 1

Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separ ...[more]

PMID: 37580382

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Project description:SignificanceThe non-invasive measurement of cerebral blood flow based on diffuse optical techniques has seen increased interest as a research tool for cerebral perfusion monitoring in critical care and functional brain imaging. Diffuse correlation spectroscopy (DCS) and speckle contrast optical spectroscopy (SCOS) are two such techniques that measure complementary aspects of the fluctuating intensity signal, with DCS quantifying the temporal fluctuations of the signal and SCOS quantifying the spatial blurring of a speckle pattern. With the increasing interest in the use of these techniques, a thorough comparison would inform new adopters of the benefits of each technique.AimWe systematically evaluate the performance of DCS and SCOS for the measurement of cerebral blood flow.ApproachMonte Carlo simulations of dynamic light scattering in an MRI-derived head model were performed. For both DCS and SCOS, estimates of sensitivity to cerebral blood flow changes, coefficient of variation of the measured blood flow, and the contrast-to-noise ratio of the measurement to the cerebral perfusion signal were calculated. By varying complementary aspects of data collection between the two methods, we investigated the performance benefits of different measurement strategies, including altering the number of modes per optical detector, the integration time/fitting time of the speckle measurement, and the laser source delivery strategy.ResultsThrough comparison across these metrics with simulated detectors having realistic noise properties, we determine several guiding principles for the optimization of these techniques and report the performance comparison between the two over a range of measurement properties and tissue geometries. We find that SCOS outperforms DCS in terms of contrast-to-noise ratio for the cerebral blood flow signal in the ideal case simulated here but note that SCOS requires careful experimental calibrations to ensure accurate measurements of cerebral blood flow.ConclusionWe provide design principles by which to evaluate the development of DCS and SCOS systems for their use in the measurement of cerebral blood flow.

Dataset Information

Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

Publications

Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

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