Ontology highlight
ABSTRACT:
SUBMITTER: Jana S
PROVIDER: S-EPMC10425985 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Jana Santanu S Rajasekaran Parasuraman P Haldimann Klara K Vasella Andrea A Böttger Erik C EC Hobbie Sven N SN Crich David D
ACS infectious diseases 20230723 8
Complementing our earlier syntheses of the gentamicins B1, C1a, C2b, and X2, we describe the synthesis of gentamicins C1, C2, and C2a characterized by methyl substitution at the 6'-position, and so present an alternative access to previous chromatographic methods for accessing these sought-after compounds. We describe the antiribosomal activity of our full set of synthetic gentamicin congeners against bacterial ribosomes and hybrid ribosomes carrying the decoding A site of the human mitochondria ...[more]