Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC10427357 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Yang Qingbin Q Lei Xuetao X He Jiayong J Peng Yanmei Y Zhang Yihao Y Ling Ruoyu R Wu Chaorui C Zhang Guofan G Zheng Boyang B Chen Xinhua X Zou Boya B Fu Ziyi Z Zhao Liying L Liu Hao H Hu Yanfeng Y Yu Jiang J Li Fengping F Ye Gengtai G Li Guoxin G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230616 23
Anti-angiogenic therapy has long been considered a promising strategy for solid cancers. Intrinsic resistance to hypoxia is a major cause for the failure of anti-angiogenic therapy, but the underlying mechanism remains unclear. Here, it is revealed that N4-acetylcytidine (ac4C), a newly identified mRNA modification, enhances hypoxia tolerance in gastric cancer (GC) cells by promoting glycolysis addiction. Specifically, acetyltransferase NAT10 transcription is regulated by HIF-1α, a key transcrip ...[more]