REPTOR and CREBRF encode key regulators of muscle energy metabolism.
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ABSTRACT:
SUBMITTER: Saavedra P
PROVIDER: S-EPMC10427696 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
REPTOR and CREBRF encode key regulators of muscle energy metabolism.
Saavedra Pedro P Dumesic Phillip A PA Hu Yanhui Y Filine Elizabeth E Jouandin Patrick P Binari Richard R Wilensky Sarah E SE Rodiger Jonathan J Wang Haiyun H Chen Weihang W Liu Ying Y Spiegelman Bruce M BM Perrimon Norbert N
Nature communications 20230815 1
Metabolic flexibility of muscle tissue describes the adaptive capacity to use different energy substrates according to their availability. The disruption of this ability associates with metabolic disease. Here, using a Drosophila model of systemic metabolic dysfunction triggered by yorkie-induced gut tumors, we show that the transcription factor REPTOR is an important regulator of energy metabolism in muscles. We present evidence that REPTOR is activated in muscles of adult flies with gut yorkie ...[more]
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