Longevity factor klotho enhances cognition in aged nonhuman primates.
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ABSTRACT:
SUBMITTER: Castner SA
PROVIDER: S-EPMC10432271 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Longevity factor klotho enhances cognition in aged nonhuman primates.
Castner Stacy A SA Gupta Shweta S Wang Dan D Moreno Arturo J AJ Park Cana C Chen Chen C Poon Yan Y Groen Aaron A Greenberg Kenneth K David Nathaniel N Boone Tom T Baxter Mark G MG Williams Graham V GV Dubal Dena B DB
Nature aging 20230703 8
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman ...[more]
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