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Normative brain mapping using scalp EEG and potential clinical application.

ABSTRACT: A normative electrographic activity map could be a powerful resource to understand normal brain function and identify abnormal activity. Here, we present a normative brain map using scalp EEG in terms of relative band power. In this exploratory study we investigate its temporal stability, its similarity to other imaging modalities, and explore a potential clinical application. We constructed scalp EEG normative maps of brain dynamics from 17 healthy controls using source-localised resting-state scalp recordings. We then correlated these maps with those acquired from MEG and intracranial EEG to investigate their similarity. Lastly, we use the normative maps to lateralise abnormal regions in epilepsy. Spatial patterns of band powers were broadly consistent with previous literature and stable across recordings. Scalp EEG normative maps were most similar to other modalities in the alpha band, and relatively similar across most bands. Towards a clinical application in epilepsy, we found abnormal temporal regions ipsilateral to the epileptogenic hemisphere. Scalp EEG relative band power normative maps are spatially stable across time, in keeping with MEG and intracranial EEG results. Normative mapping is feasible and may be potentially clinically useful in epilepsy. Future studies with larger sample sizes and high-density EEG are now required for validation.

SUBMITTER: Janiukstyte V

PROVIDER: S-EPMC10439201 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Normative brain mapping using scalp EEG and potential clinical application.

Janiukstyte Vytene V Owen Thomas W TW Chaudhary Umair J UJ Diehl Beate B Lemieux Louis L Duncan John S JS de Tisi Jane J Wang Yujiang Y Taylor Peter N PN

Scientific reports 20230818 1

A normative electrographic activity map could be a powerful resource to understand normal brain function and identify abnormal activity. Here, we present a normative brain map using scalp EEG in terms of relative band power. In this exploratory study we investigate its temporal stability, its similarity to other imaging modalities, and explore a potential clinical application. We constructed scalp EEG normative maps of brain dynamics from 17 healthy controls using source-localised resting-state ...[more]

PMID: 37596291

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Project description:OBJECTIVE:The goal of this study is to investigate the performance, merits and limitations of source imaging using intracranial EEG (iEEG) recordings and to compare its accuracy to the results of EEG source imaging. Accuracy in this study, is measured both by determining the location and inter-nodal connectivity of underlying brain networks. METHODS:Systematic computer simulation studies are conducted to evaluate iEEG-based source imaging vs. EEG-based source imaging, and source imaging using both EEG and iEEG. To test the source imaging models, networks of inter-connected nodes (in terms of activity) are simulated. The location of the network nodes is randomly selected within a realistic geometry head model and a connectivity link is created among these nodes based on a multi-variate auto-regressive (MVAR) model. Then the forward problem is solved to calculate the potentials at the electrodes and noise (white and correlated) is added to these simulated potentials to simulate realistic measurements. Subsequently, the inverse problem is solved and an algorithm based on principle component analysis is performed on the estimated source activities to determine the location of the simulated network nodes. The activity of these nodes (over time), is then extracted, and used to estimate the connectivity links among the mentioned nodes using Granger causality analysis. RESULTS:Source imaging based on iEEG recordings may or may not improve the accuracy in localization, depending on the number and location of active nodes relative to iEEG electrodes and to other nodes within the network. However, our simulation results suggest that combining EEG and iEEG modalities (simultaneous scalp and intracranial recordings) can improve the imaging accuracy significantly. CONCLUSIONS:While iEEG source imaging is useful in estimating the exact location of sources near the iEEG electrodes, combining EEG and iEEG recordings can achieve a more accurate imaging due to the high spatial coverage of the scalp electrodes and the added near field information provided by the iEEG electrodes. SIGNIFICANCE:The present results suggest the feasibility of localizing brain electrical sources from iEEG recordings and improving EEG source localization using simultaneous EEG and iEEG recordings to cover the whole brain. The hybrid EEG and iEEG source imaging can assist the clinicians when unequivocal decisions about determining the epileptogenic zone cannot be reached using a single modality.

Project description:Epilepsy is a chronic brain disease that causes persistent and severe damage to the physical and mental health of patients. Daily effective prediction of epileptic seizures is crucial for epilepsy patients especially those with refractory epilepsy. At present, a large number of deep learning algorithms such as Convolutional Neural Networks and Recurrent Neural Networks have been used to predict epileptic seizures and have obtained better performance than traditional machine learning methods. However, these methods usually transform the Electroencephalogram (EEG) signal into a Euclidean grid structure. The conversion suffers from loss of adjacent spatial information, which results in deep learning models requiring more storage and computational consumption in the process of information fusion after information extraction. This study proposes a general Graph Convolutional Networks (GCN) model architecture for predicting seizures to solve the problem of oversized seizure prediction models based on exploring the graph structure of EEG signals. As a graph classification task, the network architecture includes graph convolution layers that extract node features with one-hop neighbors, pooling layers that summarize abstract node features; and fully connected layers that implement classification, resulting in superior prediction performance and smaller network size. The experiment shows that the model has an average sensitivity of 96.51%, an average AUC of 0.92, and a model size of 15.5 k on 18 patients in the CHB-MIT scalp EEG dataset. Compared with traditional deep learning methods, which require a large number of parameters and computational effort and are demanding in terms of storage space and energy consumption, this method is more suitable for implementation on compact, low-power wearable devices as a standard process for building a generic low-consumption graph network model on similar biomedical signals. Furthermore, the edge features of graphs can be used to make a preliminary determination of locations and types of discharge, making it more clinically interpretable.

Dataset Information

Normative brain mapping using scalp EEG and potential clinical application.

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Normative brain mapping using scalp EEG and potential clinical application.

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