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ABSTRACT: Background
There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).Objectives
To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.Methods
Participants from the Tromsø Study with a first-time VTE (n = 545) were included, and all VTE recurrences and deaths among the participants were recorded in the period 1994 to 2020. Weak HGS was defined as lowest 25th percentile of the general population, and incidence rates for VTE recurrence and mortality according to weak vs normal (>25th percentile) HGS, with 95% CIs, were estimated.Results
There were 90 recurrences and 350 deaths during a median of 3.7 years of follow-up. The fully adjusted hazard ratio (HR) for overall VTE recurrence for those with weak HGS vs those with normal HGS was 2.02 (95% CI, 1.23-3.30). The corresponding HRs for recurrence were 2.22 (95% CI, 1.18-4.17) in patients with a first deep vein thrombosis and 1.60 (95% CI, 0.72-3.57) in patients with a first pulmonary embolism. The cumulative 1-year survival was 74.9% and 77.8% in those with weak and normal HGS, respectively. For overall mortality after incident VTE, the fully adjusted HR for those with weak HGS was 1.34 (95% CI, 1.04-1.72).Conclusion
Weak HGS was associated with an increased risk of recurrent VTE, and the association appeared to be particularly pronounced after incident deep vein thrombosis. There was a slightly lower survival probability among those with weak HGS than among those with normal HGS.
SUBMITTER: Leknessund OGR
PROVIDER: S-EPMC10439395 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Leknessund Oda G R OGR Morelli Vania M VM Hansen John-Bjarne JB Brækkan Sigrid K SK
Research and practice in thrombosis and haemostasis 20230629 5
<h4>Background</h4>There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<h4>Objectives</h4>To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<h4>Methods</h4>Participants from the Tromsø Study with a first-time VTE (<i>n</i> = 545) were included, and all VTE recurrences and deaths among the p ...[more]