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Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.

ABSTRACT: Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the seriousness of clinical outcomes of adverse reactions to drugs. GCAP has two tasks: one is to predict whether adverse reactions to drugs cause serious clinical outcomes, and the other is to infer the corresponding classes of serious clinical outcomes. Experimental results demonstrate that our method is a powerful and robust framework with high extendibility. GCAP can serve as a useful tool to successfully address the challenge of predicting the seriousness of clinical outcomes stemming from adverse reactions to drugs.

SUBMITTER: Zhao H

PROVIDER: S-EPMC10449791 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.

Zhao Haochen H Ni Peng P Zhao Qichang Q Liang Xiao X Ai Di D Erhardt Shannon S Wang Jun J Li Yaohang Y Wang Jianxin J

Communications biology 20230824 1

Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur ...[more]

PMID: 37620651

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Project description:IntroductionMummy berry is a serious disease that may result in up to 70 percent of yield loss for lowbush blueberries. Practical mummy berry disease detection, stage classification and severity estimation remain great challenges for computer vision-based approaches because images taken in lowbush blueberry fields are usually a mixture of different plant parts (leaves, bud, flowers and fruits) with a very complex background. Specifically, typical problems hindering this effort included data scarcity due to high manual labelling cost, tiny and low contrast disease features interfered and occluded by healthy plant parts, and over-complicated deep neural networks which made deployment of a predictive system difficult.MethodsUsing real and raw blueberry field images, this research proposed a deep multi-task learning (MTL) approach to simultaneously accomplish three disease detection tasks: identification of infection sites, classification of disease stage, and severity estimation. By further incorporating novel superimposed attention mechanism modules and grouped convolutions to the deep neural network, enabled disease feature extraction from both channel and spatial perspectives, achieving better detection performance in open and complex environments, while having lower computational cost and faster convergence rate.ResultsExperimental results demonstrated that our approach achieved higher detection efficiency compared with the state-of-the-art deep learning models in terms of detection accuracy, while having three main advantages: 1) field images mixed with various types of lowbush blueberry plant organs under a complex background can be used for disease detection; 2) parameter sharing among different tasks greatly reduced the size of training samples and saved 60% training time than when the three tasks (data preparation, model development and exploration) were trained separately; and 3) only one-sixth of the network parameter size (23.98M vs. 138.36M) and one-fifteenth of the computational cost (1.13G vs. 15.48G FLOPs) were used when compared with the most popular Convolutional Neural Network VGG16.DiscussionThese features make our solution very promising for future mobile deployment such as a drone carried task unit for real-time field surveillance. As an automatic approach to fast disease diagnosis, it can be a useful technical tool to provide growers real time disease information that can prevent further disease transmission and more severe effects on yield due to fruit mummification.

Dataset Information

Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.

Publications

Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.

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