Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC10451319 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Park Jungmi J Mahida Neel N Ho Gabrielle G Pena Elizabeth E Makabenta Jessa Marie V JMV Aneke Stanley S Jiang Mingdi M Bouthillette Leah M LM Holz Stephanie E SE Hassan Muhammad Aamir MA Wolfe Amanda L AL Rotello Vincent M VM
Antibiotics (Basel, Switzerland) 20230728 8
Multi-drug-resistant (MDR) bacteria, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), pose a significant challenge in healthcare settings. Small molecule antimicrobials (SMAs) such as α-pyrones have shown promise as alternative treatments for MDR infections. However, the hydrophobic nature of many SMAs limits their solubility and efficacy in complex biological environments. In this study, we encapsulated pseudopyronine analogs (PAs) in biodegradable polymer nanoemulsions (BNE ...[more]