Dataset Information

Glutathione: Lights and Shadows in Cancer Patients.

ABSTRACT: In cases of cellular injury, there is an observed increase in the production of reactive oxygen species (ROS). When this production becomes excessive, it can result in various conditions, including cancerogenesis. Glutathione (GSH), the most abundant thiol-containing antioxidant, is fundamental to re-establishing redox homeostasis. In order to evaluate the role of GSH and its antioxi-dant effects in patients affected by cancer, we performed a thorough search on Medline and EMBASE databases for relevant clinical and/or preclinical studies, with particular regard to diet, toxicities, and pharmacological processes. The conjugation of GSH with xenobiotics, including anti-cancer drugs, can result in either of two effects: xenobiotics may lose their harmful effects, or GSH conjugation may enhance their toxicity by inducing bioactivation. While being an interesting weapon against chemotherapy-induced toxicities, GSH may also have a potential protective role for cancer cells. New studies are necessary to better explain the relationship between GSH and cancer. Although self-prescribed glutathione (GSH) implementation is prevalent among cancer patients with the intention of reducing the toxic effects of anticancer treatments and potentially preventing damage to normal tissues, this belief lacks substantial scientific evidence for its efficacy in reducing toxicity, except in the case of cisplatin-related neurotoxicity. Therefore, the use of GSH should only be considered under medical supervision, taking into account the appropriate timing and setting.

SUBMITTER: Marini HR

PROVIDER: S-EPMC10452337 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Glutathione: Lights and Shadows in Cancer Patients.

Marini Herbert Ryan HR Facchini Bianca Arianna BA di Francia Raffaele R Freni José J Puzzolo Domenico D Montella Liliana L Facchini Gaetano G Ottaiano Alessandro A Berretta Massimiliano M Minutoli Letteria L

Biomedicines 20230808 8

In cases of cellular injury, there is an observed increase in the production of reactive oxygen species (ROS). When this production becomes excessive, it can result in various conditions, including cancerogenesis. Glutathione (GSH), the most abundant thiol-containing antioxidant, is fundamental to re-establishing redox homeostasis. In order to evaluate the role of GSH and its antioxi-dant effects in patients affected by cancer, we performed a thorough search on Medline and EMBASE databases for r ...[more]

PMID: 37626722

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Dataset Information

Glutathione: Lights and Shadows in Cancer Patients.

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Glutathione: Lights and Shadows in Cancer Patients.

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