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PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues.

ABSTRACT: Theranostics (therapy + diagnosis) targeting prostate-specific membrane antigen (PSMA) is an emerging therapeutic modality that could alter treatment strategies for prostate cancer. Although PSMA-targeted radioligand therapy (PSMA-RLT) has a highly therapeutic effect on PSMA-positive tumor tissue, the efficacy of PSMA-RLT depends on PSMA expression. Moreover, predictors of treatment response other than PSMA expression are under investigation. Therefore, the optimal patient population for PSMA-RLT remains unclear. This review provides an overview of the current status of theranostics for prostate cancer, focusing on PSMA ligands. In addition, we summarize various findings regarding the efficacy and problems of PSMA-RLT and discuss the optimal patient for PSMA-RLT.

SUBMITTER: Hoshi S

PROVIDER: S-EPMC10453875 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues.

Hoshi Seiji S Yaginuma Kei K Meguro Satoru S Onagi Akifumi A Matsuoka Kanako K Hata Junya J Sato Yuichi Y Akaihata Hidenori H Kataoka Masao M Ogawa Soichiro S Uemura Motohide M Kojima Yoshiyuki Y

Current oncology (Toronto, Ont.) 20230801 8

Theranostics (therapy + diagnosis) targeting prostate-specific membrane antigen (PSMA) is an emerging therapeutic modality that could alter treatment strategies for prostate cancer. Although PSMA-targeted radioligand therapy (PSMA-RLT) has a highly therapeutic effect on PSMA-positive tumor tissue, the efficacy of PSMA-RLT depends on PSMA expression. Moreover, predictors of treatment response other than PSMA expression are under investigation. Therefore, the optimal patient population for PSMA-RL ...[more]

PMID: 37623010

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PSMA Theranostics: Review of the Current Status of PSMA-Targeted Imaging and Radioligand Therapy.

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