Dataset Information

Personalized Medicine in Cancer Pain Management.

ABSTRACT:

Background

Previous studies have documented pain as an important concern for quality of life (QoL) and one of the most challenging manifestations for cancer patients. Thus, cancer pain management (CPM) plays a key role in treating pain related to cancer. The aim of this systematic review was to investigate CPM, with an emphasis on personalized medicine, and introduce new pharmacogenomics-based procedures for detecting and treating cancer pain patients.

Methods

This study systematically reviewed PubMed from 1990 to 2023 using keywords such as cancer, pain, and personalized medicine. A total of 597 publications were found, and after multiple filtering processes, 75 papers were included. In silico analyses were performed using the GeneCards, STRING-MODEL, miRTargetLink2, and PharmGKB databases.

Results

The results reveal that recent reports have mainly focused on personalized medicine strategies for CPM, and pharmacogenomics-based data are rapidly being introduced. The literature review of the 75 highly relevant publications, combined with the bioinformatics results, identified a list of 57 evidence-based genes as the primary gene list for further personalized medicine approaches. The most frequently mentioned genes were CYP2D6, COMT, and OPRM1. Moreover, among the 127 variants identified through both the literature review and data mining in the PharmGKB database, 21 variants remain as potential candidates for whole-exome sequencing (WES) analysis. Interestingly, hsa-miR-34a-5p and hsa-miR-146a-5p were suggested as putative circulating biomarkers for cancer pain prognosis and diagnosis.

Conclusions

In conclusion, this study highlights personalized medicine as the most promising strategy in CPM, utilizing pharmacogenomics-based approaches to alleviate cancer pain.

SUBMITTER: Raad M

PROVIDER: S-EPMC10455778 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Personalized Medicine in Cancer Pain Management.

Raad Mohammad M López William Omar Contreras WOC Sharafshah Alireza A Assefi Marjan M Lewandrowski Kai-Uwe KU

Journal of personalized medicine 20230728 8

<h4>Background</h4>Previous studies have documented pain as an important concern for quality of life (QoL) and one of the most challenging manifestations for cancer patients. Thus, cancer pain management (CPM) plays a key role in treating pain related to cancer. The aim of this systematic review was to investigate CPM, with an emphasis on personalized medicine, and introduce new pharmacogenomics-based procedures for detecting and treating cancer pain patients.<h4>Methods</h4>This study systemati ...[more]

PMID: 37623452

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Dataset Information

Personalized Medicine in Cancer Pain Management.

Background

Methods

Results

Conclusions

Publications

Personalized Medicine in Cancer Pain Management.

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