Dataset Information

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.

ABSTRACT: Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation and child height in four LMIC cohorts (n = 1927) and identify a robust association at three CpGs in the suppressor of cytokine signaling 3 (SOCS3) gene which replicates in a high-income country cohort (n = 879). SOCS3 methylation (SOCS3m)-height associations are independent of genetic effects. Mendelian randomization analysis confirms a causal effect of SOCS3m on height. In longitudinal analysis, SOCS3m explains a maximum 9.5% of height variance in mid-childhood while the variance explained by height polygenic risk score increases from birth to 21 years. Children's SOCS3m is associated with prenatal maternal folate and socio-economic status. In-vitro characterization confirms a regulatory effect of SOCS3m on gene expression. Our findings suggest epigenetic modifications may play an important role in driving child height in LMIC.

SUBMITTER: Issarapu P

PROVIDER: S-EPMC10457295 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.

Issarapu Prachand P Arumalla Manisha M Elliott Hannah R HR Nongmaithem Suraj S SS Sankareswaran Alagu A Betts Modupeh M Sajjadi Sara S Kessler Noah J NJ Bayyana Swati S Mansuri Sohail R SR Derakhshan Maria M Krishnaveni G V GV Shrestha Smeeta S Kumaran Kalyanaraman K Di Gravio Chiara C Sahariah Sirazul A SA Sanderson Eleanor E Relton Caroline L CL Ward Kate A KA Moore Sophie E SE Prentice Andrew M AM Lillycrop Karen A KA Fall Caroline H D CHD Silver Matt J MJ Chandak Giriraj R GR

Nature communications 20230825 1

Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation and child height in four LMIC cohorts (n = 1927) and identify a robust association at three CpGs in the suppressor of cytokine signaling 3 (SOCS3) gene which replicates in a high-income country cohort (n = 879). SOCS3 methylation (SOCS3m)-height associations are independe ...[more]

PMID: 37626025

Dataset Information

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.

Publications

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.

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