Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC10457384 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Liu Wenzhe W Chen Limin L Yin Dongbao D Yang Zhiheng Z Feng Jianfei J Sun Qi Q Lai Luhua L Guo Xuefeng X
Nature communications 20230825 1
Intrinsically disordered proteins (IDPs) play crucial roles in cellular processes and hold promise as drug targets. However, the dynamic nature of IDPs remains poorly understood. Here, we construct a single-molecule electrical nanocircuit based on silicon nanowire field-effect transistors (SiNW-FETs) and functionalize it with an individual disordered c-Myc bHLH-LZ domain to enable label-free, in situ, and long-term measurements at the single-molecule level. We use the device to study c-Myc inter ...[more]