Ontology highlight
ABSTRACT:
SUBMITTER: Jiang F
PROVIDER: S-EPMC10460848 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Jiang Fangli F Jia Keren K Chen Yang Y Ji Congcong C Chong Xiaoyi X Li Zhongwu Z Zhao Feilong F Bai Yuezong Y Ge Sai S Gao Jing J Zhang Xiaotian X Li Jian J Shen Lin L Zhang Cheng C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230621 24
The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance. Combining clinical cohorts, multi-omics study, and functional/molecular experiments, it is found that ANO1 amplification or high-expression predicts poor outcomes and resistance to immunotherapy for GI cancer patients. Knocking-down or inhibiting ANO1 suppresses the growth/metastasis/invasion of multiple GI cancer cell lines, cell-derived ...[more]