Dataset Information

Ictal and interictal SPECT with ^99m Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

ABSTRACT:

Objective

This retrospective study investigates the predictive value of ictal subtraction single-photon emission computed tomography (SPECT) co-registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery.

Methods

57 patients examined with SISCOM as a part of epilepsy surgery evaluation were divided into two groups based on seizure duration after tracer injection (group 1: Seizure duration above or equal to 30 s, group 2: Seizure duration under 30 s). SISCOM was compared to the surgical site and categorized as good or poor concordance. Subsequently, Odds ratios (ORs) and positive predictive values (PPVs) were calculated for each group for good surgical outcome, freedom from disabling seizures.

Results

The PPVs and ORs for good surgical outcome was 74.1% and 5.71 for group 1 and 40% and 0.22 for group 2. SISCOM had a similar positive predictive value regardless of whether the focus was in the same or neighboring lobe, but same hemisphere as the resection.

Conclusion

In conclusion, the implementation of a precise definition for a well-executed ictal SPECT scan with respect to seizure duration after injection enhances the positive predictive value (PPV) and odds ratio (OR) for successful surgical outcome, surpassing previous findings, whether the focus in resected lobe or the neighboring.

SUBMITTER: Prener M

PROVIDER: S-EPMC10472396 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Ictal and interictal SPECT with <sup>99m</sup> Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

Prener Martin M Drejer Veronica V Ziebell Morten M Jensen Per P Madsen Camilla Gøbel CG Olsen Svitlana S Thomsen Gerda G Pinborg Lars H LH Paulson Olaf B OB

Epilepsia open 20230725 3

<h4>Objective</h4>This retrospective study investigates the predictive value of ictal subtraction single-photon emission computed tomography (SPECT) co-registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery.<h4>Methods</h4>57 patients examined with SISCOM as a part of epilepsy surgery evaluation were divided into two groups based on seizure duration after tracer injection (group 1: Seizure duration above or equal to 30 s, group 2: Seizure duration under 30 s). SI ...[more]

PMID: 37464953

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Dataset Information

Ictal and interictal SPECT with ^99m Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

Objective

Methods

Results

Conclusion

Publications

Ictal and interictal SPECT with <sup>99m</sup> Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Ictal and interictal SPECT with 99m Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

Objective

Methods

Results

Conclusion

Publications

Ictal and interictal SPECT with <sup>99m</sup> Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Ictal and interictal SPECT with ^99m Tc-HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations.