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Second-generation extracellular matrix patch for epicardial infarct repair.

ABSTRACT: Current myocardial infarction treatments focus on improving hemodynamics rather than addressing the problem of lost myocardium impairing left ventricular function. Epicardial infarct repair with a bioactive patch placed on the ischemic area is an emerging approach to promote endogenous myocardial repair. We report the use of a second-generation CorMatrix-extracellular matrix (ECM) patch as an adjunct to surgical revascularization in treating a young patient with diffuse, multivessel coronary artery disease unamenable to PCI and a large anterior myocardial infarction. The progressive myocardial scar shrinkage and increase in left ventricular ejection fraction from 10 to 51% are generally not observed with surgical revascularization therapy alone, suggesting this new patch has adjunctive potential to current revascularization therapy.

SUBMITTER: Bhatt A

PROVIDER: S-EPMC10474747 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Second-generation extracellular matrix patch for epicardial infarct repair.

Bhatt Arjun A Bates Michael J MJ Marcu Constantin B CB Matheny Robert G RG Carabello Blase A BA Yin Kanhua K Boyd Walter Douglas WD

Journal of cardiothoracic surgery 20230901 1

Current myocardial infarction treatments focus on improving hemodynamics rather than addressing the problem of lost myocardium impairing left ventricular function. Epicardial infarct repair with a bioactive patch placed on the ischemic area is an emerging approach to promote endogenous myocardial repair. We report the use of a second-generation CorMatrix-extracellular matrix (ECM) patch as an adjunct to surgical revascularization in treating a young patient with diffuse, multivessel coronary art ...[more]

PMID: 37658440

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