Ontology highlight
ABSTRACT:
SUBMITTER: Peng X
PROVIDER: S-EPMC10475788 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Peng Xiyu X Lee Jasme J Adamow Matthew M Maher Colleen C Postow Michael A MA Callahan Margaret K MK Panageas Katherine S KS Shen Ronglai R
Cell reports methods 20230802 8
We present TopicFlow, a computational framework for flow cytometry data analysis of patient blood samples for the identification of functional and dynamic topics in circulating T cell population. This framework applies a Latent Dirichlet Allocation (LDA) model, adapting the concept of topic modeling in text mining to flow cytometry. To demonstrate the utility of our method, we conducted an analysis of ∼17 million T cells collected from 138 peripheral blood samples in 51 patients with melanoma un ...[more]