Ontology highlight
ABSTRACT:
SUBMITTER: Nagira Y
PROVIDER: S-EPMC10477828 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Nagira Yoji Y Nagira Morio M Nagai Ryohei R Nogami Wataru W Hirata Michinari M Ueyama Azumi A Yoshida Tetsuya T Yoshikawa Mai M Shinonome Satomi S Yoshida Hiroshi H Haruna Miya M Miwa Hiroto H Chatani Natsumi N Ohkura Naganari N Wada Hisashi H Tanaka Hidekazu H
Molecular cancer therapeutics 20230901 9
Although regulatory T cells (Treg) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote tumor growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating Tregs is, therefore, expected to activate antitumor immunity without affecting immune homeostasis. We previously reported that selective Treg depletion targeted by a C-C motif chemokine receptor 8 (CCR8) resulted in induction of strong antitumor imm ...[more]