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ABSTRACT: Objective
To estimate the prevalence and risk factors associated with tuberculosis (TB) among people living with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) in China.Methods
A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. After the literature was screened based on the inclusion and exclusion criteria, STATA® version 17.0 software was used for the meta-analysis. The heterogeneity among study data was assessed using I2 statistics. Subgroup analysis and meta-regressions were performed to further explore the source of heterogeneity.Results
A total of 5241 studies were retrieved. Of these, 44 studies were found to be eligible. The pooled prevalence of HIV/TB co-infection was 6.0%. The risk factors for HIV/TB co-infection included a low CD4+ T cell count, smoking, intravenous drug use and several other sociodemographic and clinical factors. Bacillus Calmette-Guérin (BCG) vaccination history was a protective factor.Conclusion
A high prevalence of TB was observed among people living with HIV/AIDS in China. Low CD4+ T cell count, smoking, and intravenous drug use were the primary risk factors for HIV/TB co-infection, whereas BCG vaccination history was a protective factor. Checking for TB should be prioritized in HIV screening and healthcare access.Systematic review registration
Registered on PROSPERO, Identifier: CRD42022297754.
SUBMITTER: Qi CC
PROVIDER: S-EPMC10481577 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Qi Cong-Cong CC Xu Li-Ran LR Zhao Chang-Jia CJ Zhang Hai-Yan HY Li Qing-Ya QY Liu Mei-Jun MJ Zhang Ye-Xuan YX Tang Zhou Z Ma Xiu-Xia XX
BMC infectious diseases 20230906 1
<h4>Objective</h4>To estimate the prevalence and risk factors associated with tuberculosis (TB) among people living with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) in China.<h4>Methods</h4>A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. After the literature was screened based on the inclusion and exclusion criteria, STATA<sup>®</sup> version 17.0 softwa ...[more]