Ontology highlight
ABSTRACT:
SUBMITTER: Hayne CK
PROVIDER: S-EPMC10485636 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Hayne Cassandra K CK Sekulovski Samoil S Hurtig Jennifer E JE Stanley Robin E RE Trowitzsch Simon S van Hoof Ambro A
The Journal of biological chemistry 20230805 9
Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical function in the maturation of intron-containing pre-tRNAs. The catalytic mechanism and core requirement for this process is conserved between archaea and eukaryotes, but for decades, it has been known that eukaryotic TSENs have evolved additional modes of RNA recognition, which have remained poorly understood. Recent research identified new roles for eukaryotic TSEN, including processing or degradation of add ...[more]