Ontology highlight
ABSTRACT:
SUBMITTER: Zetzsche H
PROVIDER: S-EPMC10500059 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Zetzsche Heidi H Raschke Laura L Fürtig Boris B
Frontiers in molecular biosciences 20230831
The <i>E. coli</i> DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome. The allosteric interaction with complex partner RNase E is necessary to stimulate both, RhlB's ATPase and RNA unwinding activity to levels comparable with other DEAD-Box helicases. However, the structural changes of the helicase RhlB induced by binding of RNase E have not been characterized and how those lead to increased reacti ...[more]