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Borna disease in a dog with lethal meningoencephalitis.

ABSTRACT: A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.

SUBMITTER: Weissenbock H

PROVIDER: S-EPMC105002 | biostudies-literature | 1998 Jul

REPOSITORIES: biostudies-literature

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Borna disease in a dog with lethal meningoencephalitis.

Weissenböck H H Nowotny N N Caplazi P P Kolodziejek J J Ehrensperger F F

Journal of clinical microbiology 19980701 7

A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog. ...[more]

PMID: 9650982

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