Ontology highlight
ABSTRACT:
SUBMITTER: Cheng F
PROVIDER: S-EPMC10502670 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Cheng Furong F Su Ting T Liu Yangtengyu Y Zhou Shurong S Qi Jialong J Guo Weisheng W Zhu Guizhi G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230712 26
Rheumatoid arthritis (RA) is a systemic autoimmune disease with pathogenic inflammation caused partly by excessive cell-free DNA (cfDNA). Specifically, cfDNA is internalized into immune cells, such as macrophages in lymphoid tissues and joints, and activates pattern recognition receptors, including cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), resulting in overly strong proinflammation. Here, nanomedicine-in-hydrogel (NiH) is reported that co-delivers cGAS inhibitor RU. ...[more]