Dataset Information

A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.

ABSTRACT:

Background

Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed.

Objective

We sought to detect genetic variants associated with differences in immune responsiveness against allergen components.

Methods

The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen components analyzed, n = 31), as well as against allergen protein families (allergen protein group sensitization, number of protein groups analyzed, n = 16).

Results

We performed GWAS on 564 participants of the Tokyo Children's Health, Illness, and Development study and found associations between Amb a 1 sensitization and the immunoglobulin heavy-chain variable gene on chromosome 14 and between Phl p 1 sensitization and the HLA class II region on chromosome 6 (P < 5.0 × 10^-8). A GWAS-significant association was also observed between the HLA class II region and profilin sensitization (P < 5.0 × 10^-8).

Conclusions

Our data provide the first demonstration of genetic risk for allergen component sensitization and show that this genetic risk is related to immune response genes including immunoglobulin heavy-chain variable gene and HLA.

SUBMITTER: Morii W

PROVIDER: S-EPMC10509904 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.

Morii Wataru W Kasai Koki K Nakamura Takako T Hayashi Daisuke D Hara Monami M Naito Tatsuhiko T Sonehara Kyuto K Fukuie Tatsuki T Saito-Abe Mayako M Yang Limin L Yamamoto-Hanada Kiwako K Narita Masami M Maruo Kazushi K Okada Yukinori Y Noguchi Emiko E Ohya Yukihiro Y

The journal of allergy and clinical immunology. Global 20230220 2

<h4>Background</h4>Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed.<h4>Objective</h4>We sought to detect genetic variants associated with differences in immune responsiveness against allergen components.<h4>Methods</h4>The participants of the present study were recruited from the Tokyo Child ...[more]

PMID: 37780799

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Dataset Information

A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.

Background

Objective

Methods

Results

Conclusions

Publications

A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.

Similar Datasets

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