5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes.

ABSTRACT:

Background

5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet. Accumulating evidence suggests a role in metabolic dysfunction associated with obesity, diabetes, and fatty liver disease. However, whether 5-AVAB plays a role in human disease is unclear, and human data are sparse.

Methods

We measured circulating 5-AVAB serum levels in 143 individuals with overweight or obesity participating in a randomized intervention study (NCT00850629) investigating the long-term effect of a weight maintenance strategy after diet-induced weight reduction.

Results

Higher 5-AVAB serum levels correlate with worse estimates of obesity, glucose metabolism, and hepatic s

SUBMITTER: Haberbosch L 

PROVIDER: S-EPMC10511423 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature