Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC10511813 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Kim Joohwan J Chun Yujin Y Ramirez Cuauhtemoc B CB Hoffner Lauren A LA Jung Sunhee S Jang Ki-Hong KH Rubtsova Varvara I VI Jang Cholsoon C Lee Gina G
The Journal of biological chemistry 20230819 9
N<sup>6</sup>-adenosine methylation (m<sup>6</sup>A) is the most abundant mRNA modification that controls gene expression through diverse mechanisms. Accordingly, m<sup>6</sup>A-dependent regulation of oncogenes and tumor suppressors contributes to tumor development. However, the role of m<sup>6</sup>A-mediated gene regulation upon drug treatment or resistance is poorly understood. Here, we report that m<sup>6</sup>A modification of mitogen-activated protein kinase 13 (MAPK13) mRNA determines th ...[more]