Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC10513295 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Xu Dongwei D Vincent Alec A González-Gutiérrez Andrés A Aleyakpo Benjamin B Anoar Sharifah S Giblin Ashling A Atilano Magda L ML Adams Mirjam M Shen Dunxin D Thoeng Annora A Tsintzas Elli E Maeland Marie M Isaacs Adrian M AM Sierralta Jimena J Niccoli Teresa T
PLoS genetics 20230921 9
Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, it's unclear if the two are linked. Glucose metabolism in the brain is highly coupled between neurons and glia, with glucose taken up by glia and metabolised to lactate, which is then shuttled via transporters to ne ...[more]