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DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas.

ABSTRACT: Registration of data to a common frame of reference is an essential step in the analysis and integration of diverse neuroscientific data. To this end, volumetric brain atlases enable histological datasets to be spatially registered and analyzed, yet accurate registration remains expertise-dependent and slow. In order to address this limitation, we have trained a neural network, DeepSlice, to register mouse brain histological images to the Allen Brain Common Coordinate Framework, retaining registration accuracy while improving speed by >1000 fold.

SUBMITTER: Carey H

PROVIDER: S-EPMC10514056 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas.

Carey Harry H Pegios Michael M Martin Lewis L Saleeba Chris C Turner Anita J AJ Everett Nicholas A NA Bjerke Ingvild E IE Puchades Maja A MA Bjaalie Jan G JG McMullan Simon S

Nature communications 20230921 1

Registration of data to a common frame of reference is an essential step in the analysis and integration of diverse neuroscientific data. To this end, volumetric brain atlases enable histological datasets to be spatially registered and analyzed, yet accurate registration remains expertise-dependent and slow. In order to address this limitation, we have trained a neural network, DeepSlice, to register mouse brain histological images to the Allen Brain Common Coordinate Framework, retaining regist ...[more]

PMID: 37735467

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